According to a new study published in the January 13th issue of the medical journal Archives of Internal Medicine, patients taking serotonin reuptake inhibitors (SSRIs) in combination with nonsteroidal anti-inflammatory drugs (NSAIDs) are 12 times more likely to suffer from upper gastrointestinal bleeding than those who use neither class of medications. As part of their research, scientists from the Danish Cancer Society in Copenhagen analyzed data from 25,000 patients who used SSRIs--antidepressant drugs including Paxil and Prozac--in North Jutland County between 1991 and 1995. Researchers found that people using SSRIs alone were 3.6 times more likely to suffer from bleeding than those not using the medications and 12.2 times more likely to experience gastrointestinal bleeding when SSRIs were used in combination with NSAIDs, such as ibuprofen.